Placental Progesterone Membrane Receptors in Fetal Growth Restriction

Conditions: Fetal Growth Restriction, Placenta, Progesterone Membrane Receptor, PGRMC1, PGRMC2, Placental Dysfunction, Pregnancy

Sex: Female

Ages: 18 Years – 45 Years

Healthy volunteers: Yes

Enrollment: 90

Sponsor: Samsun University

Location: Samsun University Faculty of Medicine Samsun Training and Research Hospital Samsun

Summary

This prospective observational case-control study aims to compare placental expression levels of progesterone membrane receptors, including PGRMC1, PGRMC2, and PAQR family receptors, between pregnancies complicated by intrauterine growth restriction (IUGR) and uncomplicated healthy pregnancies. Placental tissue samples obtained at delivery will be analyzed using quantitative real-time polymerase chain reaction (qRT-PCR). The study also aims to investigate the association between receptor expression levels and perinatal outcomes in order to better understand the role of progesterone membrane receptors in the pathophysiology of IUGR.

Eligibility Criteria

Inclusion Criteria: Singleton pregnancy Maternal age 18-45 years Diagnosis of IUGR according to institutional criteria Exclusion Criteria: Multiple pregnancy Major fetal structural anomaly Chromosomal abnormality Congenital infection Maternal chronic systemic disease Autoimmune disease Chronic hypertension Pregestational diabetes mellitus Placental abruption Intrauterine fetal demise

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View on ClinicalTrials.gov

Source: ClinicalTrials.gov (NCT07701837). StuddyBuddy aggregates publicly available trial information.