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NCT07702526
Eye-Movement Intervention for Cognitive Impairment Across Schizophrenia Spectrum
Conditions: Schizophrenia, Cognitive Impairment, Clinical High Risk for Psychosis
Sex: All
Ages: 15 Years – 45 Years
Healthy volunteers: Yes
Phase: NA
Enrollment: 160
Sponsor: Shanghai Mental Health Center
Summary
The goal of this clinical trial is to determine whether a gamified eye-movement intervention can improve cognitive function in individuals across the schizophrenia spectrum, including clinical high-risk individuals, first-episode schizophrenia patients, and chronic schizophrenia patients. The main questions it aims to answer are:
* Does eye-movement training improve cognitive performance measured by the MATRICS Consensus Cognitive Battery (MCCB)?
* Does eye-movement training improve oculomotor functions and clinical symptoms across different illness stages?
Researchers will compare an eye-movement intervention group with an active control group receiving matched finger-controlled game training to determine whether the eye-movement intervention produces greater improvements in cognitive function and eye-movement performance.
Participants will:
* Receive either gamified eye-movement training or matched finger-controlled game training for 4 weeks.
* Complete cognitive assessments using the MCCB before and after the intervention.
* Complete standardized eye-tracking tasks, including fixation stability, smooth pursuit, antisaccade, and free-viewing tasks, to evaluate changes in oculomotor control and visual exploration patterns.
* Complete clinical symptom assessments using SOPS or PANSS according to illness stage.
Eligibility Criteria
Inclusion Criteria:
* Age between 15 and 45 years.
* More than 9 years of education.
* Normal or corrected-to-normal vision without color blindness, color weakness, strabismus, or nystagmus.
* Right-handedness.
* Impaired cognitive performance defined as a T-score \
Source: ClinicalTrials.gov (NCT07702526). StuddyBuddy aggregates publicly available trial information.