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Not Yet Recruiting NCT07702526

Eye-Movement Intervention for Cognitive Impairment Across Schizophrenia Spectrum

Conditions: Schizophrenia, Cognitive Impairment, Clinical High Risk for Psychosis

Sex: All
Ages: 15 Years – 45 Years
Healthy volunteers: Yes
Phase: NA
Enrollment: 160
Sponsor: Shanghai Mental Health Center

Summary

The goal of this clinical trial is to determine whether a gamified eye-movement intervention can improve cognitive function in individuals across the schizophrenia spectrum, including clinical high-risk individuals, first-episode schizophrenia patients, and chronic schizophrenia patients. The main questions it aims to answer are: * Does eye-movement training improve cognitive performance measured by the MATRICS Consensus Cognitive Battery (MCCB)? * Does eye-movement training improve oculomotor functions and clinical symptoms across different illness stages? Researchers will compare an eye-movement intervention group with an active control group receiving matched finger-controlled game training to determine whether the eye-movement intervention produces greater improvements in cognitive function and eye-movement performance. Participants will: * Receive either gamified eye-movement training or matched finger-controlled game training for 4 weeks. * Complete cognitive assessments using the MCCB before and after the intervention. * Complete standardized eye-tracking tasks, including fixation stability, smooth pursuit, antisaccade, and free-viewing tasks, to evaluate changes in oculomotor control and visual exploration patterns. * Complete clinical symptom assessments using SOPS or PANSS according to illness stage.

Eligibility Criteria

Inclusion Criteria: * Age between 15 and 45 years. * More than 9 years of education. * Normal or corrected-to-normal vision without color blindness, color weakness, strabismus, or nystagmus. * Right-handedness. * Impaired cognitive performance defined as a T-score \

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View on ClinicalTrials.gov

Source: ClinicalTrials.gov (NCT07702526). StuddyBuddy aggregates publicly available trial information.