High-Intensity Peripheral Magnetic Stimulation in Traumatic Peripheral Nerve Injury

Traumatic peripheral nerve injury is a common cause of chronic neuropathic pain, muscle weakness, and functional limitation, particularly in young and active individuals. Current conservative and pharmacological treatments often provide incomplete relief or carry side effects. High-intensity peripheral magnetic stimulation (PMS) is a non-invasive method that may help reduce neuropathic pain and support motor recovery, but evidence in traumatic nerve injury is limited. This randomized, double-blind, sham-controlled trial aims to evaluate whether high-intensity PMS, added to a standardized therapeutic exercise program, improves pain, function, quality of life, and electrophysiological measures in adults with traumatic peripheral nerve injury. Participants will be randomly assigned to receive either active PMS or sham PMS, in addition to the same exercise program. Outcomes will be assessed at baseline, 4 weeks, and 8 weeks.

Inclusion Criteria: * Age between 18 and 65 years * Traumatic peripheral nerve injury * Unilateral traumatic peripheral neuropathy confirmed by electromyography (EMG) * Nerve injury occurring at least 3 months prior * Douleur Neuropathique 4 (DN4) score ≥ 4 * Visual Analog Scale (VAS) score ≥ 4 * Manual Muscle Testing score \< 5 * No analgesic use, or stable analgesic therapy for the past month (no dose changes) Exclusion Criteria: * Active infection or malignancy * Metal implant or shrapnel in the application area * Electronic implants (e.g., cardiac pacemaker, spinal cord stimulator, deep brain stimulator) * Central nervous system diseases * Non-traumatic causes of neuropathy (e.g., radiculopathy, diabetic neuropathy, entrapment neuropathies, HIV-related neuropathy, trigeminal neuralgia) * Complete nerve injury * Injury involving three or more peripheral nerves or plexus injury * History of peripheral nerve surgery or injection within the past 3 months * Active psychiatric illness * Coagulopathy