Blinding Integrity Assessment Using Rotational Field Transcranial Magnetic Stimualtion (rfTMS) in Healthy Adults

Sex: All

Ages: 18 Years – 65 Years

Healthy volunteers: Yes

Phase: NA

Enrollment: 60

Sponsor: Soroka University Medical Center

Summary

This study evaluates the effectiveness of an improved blinding method using rotational field transcranial magnetic stimulation (rfTMS) delivered through a multi-channel deep coil system (Brainsway, Jerusalem, Israel). Healthy volunteers receive a single session of either Active or Sham stimulation over the medial prefrontal cortex. The study assesses whether the Sham condition sufficiently masks the sensory characteristics of Active stimulation. Findings will support the optimization of blinding procedures for future deep TMS (dTMS) trials.

Eligibility Criteria

Inclusion Criteria: * Healthy adults aged 18-65 * Hebrew or English speakers * No neurological, psychiatric, or developmental disorders * No contraindications for TMS * Able to provide informed consent Exclusion Criteria: * History of seizure * Metal implants in the head or neck * Pacemakers or implanted stimulators * Pregnancy * Current psychoactive medication affecting seizure threshold * Any contraindication listed in standard TMS safety guidelines

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View on ClinicalTrials.gov

Source: ClinicalTrials.gov (NCT07706790). StuddyBuddy aggregates publicly available trial information.