This a Clinical Trial to Evaluate the Efficacy of I-PRF, Povidone-Iodine and Laser as Adjuncts to Non-surgical Periodontal Treatment in Smokers and Non-Smokers Periodontitis Patients

This study is a randomized, controlled, split-mouth clinical trial designed to evaluate and compare the effectiveness of four different subgingival adjuncts used along side standard Scaling and Root Planning (SRP). This protocol is designed to be a standardized therapeutic model. The subgingival adjuncts are standardized, ensuring that the results are not operator dependent and can be replicated across any dental unit. The primary goal of this study is to evaluate the clinical efficacy of three distinct adjunctive strategies: Biological (I-PRF), Antiseptic : Povidone- iodine , Diode-Laser activation, compared to a Saline Control in the initial treatment of stage 2, 3 and stage 4 of the 2018 AAP/EFP periodontal classification.

Inclusion: Patients with Stage II-IV Periodontitis; at least one bleeding pocket \> 4 mm minimum in every quadrant. Exclusion: patients who: * Pregnant /Lactating * History of radiotherapy or chemotherapy in the head/neck region. * Known hypersensitivity to Iodine or Methylene blue solution * Systematic antibiotic use within the last 30 days * Long-term use of immunosuppressants or corticosteroids (daily use) * type 1 / 2 diabetes