Heart Rate Variability and Medication Adherence in Resistant Hypertension

Conditions: Resistant Hypertension, Medication Adherence, Autonomic Nervous System

Sex: All

Ages: 18 Years – 75 Years

Healthy volunteers: No

Enrollment: 150

Sponsor: Nemocnice AGEL Trinec-Podlesi a.s.

Location: Nemocnice AGEL Třinec-Podlesí a.s. Třinec Moravian-Silesian Region

Summary

This single-center, cross-sectional observational study examines the relationship between adherence to antihypertensive therapy - verified objectively by therapeutic drug monitoring (TDM) - and heart rate variability (HRV) in patients with resistant hypertension. Patients are recruited opportunistically, in a nurse-led manner, in a one-day-care cardiology unit, and undergo a single examination: a short-term HRV recording (Polar H10), a single blood draw for antihypertensive drug levels, office blood pressure, and self-completed questionnaires. There is no follow-up.

Eligibility Criteria

Inclusion Criteria: * Age 18-75 years with diagnosed essential hypertension * Treated with ≥3 antihypertensive drugs of different classes, including ≥1 diuretic (resistant hypertension) * Sinus rhythm * Able to give informed consent and understand Czech Exclusion Criteria: * Absence of sinus rhythm: atrial fibrillation/flutter, ventricular arrhythmias, higher-degree AV block, pacemaker/ICD with sustained pacing, sustained SVT, or significant ectopy * Secondary hypertension * Pregnancy or breastfeeding * Cognitive impairment precluding informed consent

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View on ClinicalTrials.gov

Source: ClinicalTrials.gov (NCT07707583). StuddyBuddy aggregates publicly available trial information.