The Effect of Channa Striata and Curcuma Supplementation on Nutritional Status, Interleukin-6 Levels, and Quality of Life in Patients With Breast Cancer.

Breast cancer is frequently accompanied by chronic inflammation, malnutrition, and reduced quality of life, all of which may compromise treatment response and clinical outcomes. Nutritional interventions with immunomodulatory and anti-inflammatory properties have the potential to improve these conditions. Channa striata is rich in high-quality protein, albumin, and essential amino acids that support nutritional recovery and tissue repair, while Curcuma contains curcumin, a bioactive compound with well-established anti-inflammatory and antioxidant effects. This study aims to evaluate the effect of combined Channa striata and Curcuma supplementation on nutritional status, serum interleukin-6 (IL-6) levels, and quality of life in patients with breast cancer undergoing treatment. The findings are expected to provide evidence for the use of this nutritional supplementation as a complementary strategy to improve clinical outcomes, reduce systemic inflammation, and enhance the overall well-being of breast cancer patients.

Inclusion Criteria: * Female patients with breast cancer aged ≥18 years who were undergoing chemotherapy. * Patients with a body mass index (BMI) of 18-29 kg/m². * Patients currently receiving chemotherapy for breast cancer. * Patients with serum albumin levels of 2.0-3.5 g/dL. * Patients who were able to consume oral food and were willing to participate in the study by providing written informed consent. Exclusion Criteria: * Patients with chronic kidney disease, renal failure, or kidney infection. * Patients with a known allergy to fish or Channa striata (snakehead fish) albumin-derived products. * Patients receiving other protein or amino acid supplements during the study period. * Patients who were non-compliant or discontinued the intervention before completion of the study.