Combating Age-related Failure of Myelination in Multiple Sclerosis: An Exploratory Study

This observational, longitudinal study will examine whether physical activity and other potentially modifiable lifestyle factors are associated with changes in myelin, the protective coating around nerve fibers, in older adults with multiple sclerosis (MS). Participants will undergo magnetic resonance imaging (MRI) scans to measure myelin throughout the central nervous system and will wear wrist-worn activity trackers to assess physical activity over time.

Inclusion Criteria: * Diagnosis of multiple sclerosis * Independent with ambulation (able to walk 500m without aid) * Disease duration \>10 years * Age 50 to 70 years (inclusive) * Be able to read, speak, and understand English Exclusion Criteria: * Diagnosis of other neurologic disease that would interfere with interpretation such as stroke, myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), neuromyelitis optica (NMO), and sarcoidosis. * Inability to complete study procedures (including obtaining MRI at BMIC and using Fitbit connected to smartphone) * Currently participating in another clinical trial on remyelination * Pregnancy. (Pregnancy status will be asked at screening and before each MRI. Pregnancy testing will not be offered as part of this study.)