The Effectiveness and Safety of Combined Research on Uremic Sarcopenia

Objective: To investigate the clinical efficacy and safety of mindfulness meditation during dialysis combined with pre-dialysis progressive resistance training (PRT) for sarcopenia in patients undergoing maintenance hemodialysis (MHD). Methods: In the randomized controlled trial, 76 MHD patients with sarcopenia were divided into three groups: control group (CG), sports group (SG), and intervention group (IG). All groups received standard dialysis, health education, and dietary guidance. The SG received pre-dialysis PRT, while the IG added mindfulness meditation during dialysis. Efficacy and safety were evaluated at baseline and after 12 weeks. Ultrasound assessments of muscle mass were conducted at baseline, week 4, week 8, and week 12.

Inclusion Criteria: * Meet the updated Asian diagnostic criteria for sarcopenia * Stable vital signs and general physical condition * Willing and able to cooperate with supervised exercise training * Regular hemodialysis 3 times per week for at least 3 months Exclusion Criteria: * Acute cardiovascular or cerebrovascular events within the previous 3 months * Cognitive dysfunction affecting study cooperation and exercise completion * Severe osteoarticular or limb movement disorders preventing standardized exercise training * Active systemic infection