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NCT07727265
PyroEVs/PLIN3 Mediate Lipid Droplet-Mitochondrial Coupling in Sepsis Endothelial Injury
Conditions: Sepsis
Sex: All
Ages: 18 Years – 80 Years
Healthy volunteers: Yes
Enrollment: 180
Sponsor: Zhongda Hospital
Location: Zhongda Hospital, Southeast University Nanjing Jiangsu
Summary
Objective: To investigate the correlation of PyroEVs and PLIN3 with the severity and prognosis of sepsis patients.
Participants: Sepsis patients meeting the Sepsis 3.0 diagnostic criteria admitted to the Intensive Care Unit of Zhongda Hospital affiliated with Southeast University, as well as healthy volunteers.
Inclusion Criteria:
1. Presence of confirmed or suspected infection;
2. Sequential Organ Failure Assessment (SOFA) score increase ≥ 2 points from baseline;
3. Signed informed consent. Exclusion Criteria: Age \< 18 or \> 80 years, pregnancy, cancer patients, and individuals with diseases potentially complicated by vascular endothelial cell injury.
Primary outcome: 28-day mortality, SOFA score
Eligibility Criteria
Inclusion Criteria:
* a. Presence of confirmed or suspected infection; b. Sequential Organ Failure Assessment (SOFA) score increase ≥ 2 points from baseline; c. Signed informed consent.
Exclusion Criteria:
* Age \< 18 or \> 80 years, pregnancy, cancer patients, and individuals with diseases potentially complicated by vascular endothelial cell injury.
Source: ClinicalTrials.gov (NCT07727265). StuddyBuddy aggregates publicly available trial information.
