Exercise and Taurine Supplementation on Intramuscular Fat in Older Women With Obesity

This randomized clinical trial aims to investigate the effects of multicomponent concurrent exercise training associated or not with taurine supplementation on intramuscular fat infiltration, physical performance, transcriptomic profile, and metabolomic profile in older women with obesity. Forty women aged 60 to 75 years with obesity will be randomized into four groups: control, exercise, taurine, and exercise plus taurine. The intervention will last 16 weeks. Outcomes include magnetic resonance imaging, body composition, muscle biopsy, blood biomarkers, functional capacity tests, transcriptomic analysis, and metabolomic analysis.

Inclusion Criteria: * Female, * 60 and 75 years of age, * Body mass lower than 120 kg, * Be sedentary (not having engaged in physical exercise for at least 3 months), and * Body Mass Index between 30 and 40 kg/m². Exclusion Criteria: * alcohol consumption, * smoking, * infectious and contagious diseases, * chronic kidney diseases, * undergoing weight loss treatment, and * presenting a score ≤13 on cognitive screening using the Mini-Mental State Examination (MMSE).