Evaluation of NIPSA Using Alloplastic Bone Graft and Cross-Linked Hyaluronic Acid in theTreatment of Intrabony Defects

Sixty patients will be selected from the outpatient clinic in the Oral Medicine and Periodontology Department, Faculty of Dentistry, Mansoura University, Egypt, according to preoperative clinical and radiographic data that will be used to evaluate the bone destruction pattern.

Inclusion Criteria: 1. Age range: 35 to 65 years old. 2. Patients diagnosed with stage III. Periodontitis 3. Presence of isolated intrabony defect with PPD ≥ 6 mm, CAL ≥ 6 mm 4. Intrabony defect depth ≥3 mm. 5. Contained an intrabony defect, 3-wall intrabony defect. 6. No periodontal treatment has been administered in the previous six months. 7. Full-mouth plaque score ≤ 10%. 8. Full-mouth bleeding score ≤ 10%. - Exclusion Criteria: 1. Smokers ≥ 10 cigarettes per day 2. Patient with systemic disease. 3. Pregnant or lactating patients. 4. Patient who has traumatic occlusion. 5. Noncompliant patient. 6. Patient with multi-rooted teeth with class II \& III furcation involvement.