Biomarker Analysis Data From a Randomized Phase II Study in Patients With Nasopharyngeal Carcinoma Treated With Chemotherapy and Radiotherapy

Clinicopathological and genomic data (Next generation sequencing and IHC/CISH) in available tissues were performed in patients with nasopharyngeal carcinoma who participated in a previously conducted randomized phase II study that evaulated induction chemotherapy followed by CCRT with CCRT alone.

Inclusion Criteria: * biopsy-proven, previously untreated WHO type I, II or III NPC; * age \> or equal to 15 years * stage IIB-IVB according to the American Joint Committee on Staging of Cancer classification (AJCC 2002); * measurable or evaluable disease * no other primary tumors * performance status (PS) of 0-2 according to the Eastern Cooperative Oncology Group scale (ECOG) * adequate bone marrow, hepatic, renal and pulmonary function * adequate nutritional status to tolerate protocol treatment and * adequate mental status to follow instructions, keep appointments and provide written informed consent. Exclusion Criteria: * Secondary malignancies * age\< 15 years * ECOG PS 3-4 * Renal, hepatic, hematologic or pulmonary insufficiency