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NCT07758218
Allogeneic iNKT Cell Therapy (agenT-797) After SCT
Conditions: Allogenic Stem Cell Transplantation, Myeloid Malignancies, Lymphoid Malignancies, Acute Myeloid Leukemia, Chronic Myeloid Leukemia, Myelodysplastic Syndrome
Sex: All
Ages: 18 Years – N/A
Healthy volunteers: No
Phase: PHASE1
Enrollment: 22
Sponsor: University of Wisconsin, Madison
Location: University of Wisconsin - Madison Madison Wisconsin
Summary
The goal of this clinical trial is to learn if agenT-797 is safe to use on people undergoing allogenic hematological stem cell transplantation (SCT). The main questions it aims to answer are:
* Is agenT-797 safe to use?
* What medical problems do participants have when taking agenT-797?
Participants will receive an infusion of agenT-797 about 7 days after their allogenic SCT.
Eligibility Criteria
Inclusion Criteria:
* Age ≥18 years at the time of consent
* Adult patients anticipated to get an allogeneic hematopoietic cell transplantation (allo-SCT)
* All donor types are accepted (MMUD \[mismatched unrelated donor\], MUD \[matched unrelated donor\], MSD \[matched sibling donor\], haploidentical)
* All conditioning regimens will be accepted (MAC \[myeloablative conditioning\], RIC \[reduced-intensity conditioning\], NMAC \[non-myeloablative conditioning\])
* Karnofsky Performance Scale (KPS) \> 70
* Eligible Diagnoses:
* Acute myeloid leukemia (AML) with intermediate/high-risk features or relapsed disease
* Chronic myeloid leukemia (CML) in accelerated or blast phases
* Myelodysplastic syndrome (MDS) with intermediate/high-risk features
* Acute lymphoblastic leukemia (ALL) with high-risk features or relapsed disease
* or any patients undergoing allogeneic stem cell transplant (allo-SCT) as standard of care could be eligible
Exclusion Criteria:
* Excluded Diagnoses: Primary Myelofibrosis in the dose escalation phase and could be included in the dose-expansion phase
Source: ClinicalTrials.gov (NCT07758218). StuddyBuddy aggregates publicly available trial information.