Innovative 3D Preclinical Models for Mature B-cell Malignancies to Advance Personalized Immuno and Combination Therapies

Conditions: Chronic Lymphocytic Leukemia (CLL), Splenic Marginal Zone Lymphoma, Hairy Cell Leukemia (HCL)

Sex: All

Ages: 18 Years – N/A

Healthy volunteers: No

Enrollment: 64

Sponsor: IRCCS San Raffaele

Summary

Adult patients with chronic lymphocytic leukemia (CLL), splenic marginal-zone lymphoma (SMZL) and hairy cell leukemia (HCL) followed at participating clinical sites will be enrolled and undergo sampling of additional amount of blood during the blood draws performed as part of standard clinical care. The project aims to develop and validate innovative patient-derived 3D bioprinted models that faithfully reproduce the key microenvironments of lymphoid tissues, enabling a more physiologically relevant study of mature B-cell malignancies.

Eligibility Criteria

Inclusion Criteria: * Age ≥18 years * Diagnosis of CLL, SMZL or HCL * Participant is willing and able to autonomously give informed consent for participation in the study. Exclusion Criteria: \- Participant is unable or unwilling to provide informed consent for participation in the study

Interested in this study? View the official listing for contact and enrollment details.

View on ClinicalTrials.gov

Source: ClinicalTrials.gov (NCT07759661). StuddyBuddy aggregates publicly available trial information.