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Recruiting NCT07759700

Bundle Branch Pacing to Preserve Ejection Fraction in Atrial Fibrillation Trial

Conditions: Permanent Atrial Fibrillation, Preserved Ejection Fraction

Sex: All
Ages: 18 Years – 90 Years
Healthy volunteers: No
Phase: NA
Enrollment: 642
Sponsor: Poitiers University Hospital

Location: CHU Poitiers Poitiers

Summary

The goal of this clinical trial is to learn whether left bundle branch area pacing, a technique designed to activate the heart's natural electrical conduction system, is better than conventional right ventricular pacing in adults with permanent atrial fibrillation, preserved heart pumping function, and a need for a pacemaker. The main questions it aims to answer are: Does left bundle branch area pacing reduce the risk of death, unplanned hospitalization for heart failure, or the need to replace the initial pacing system with biventricular pacing over 2 years? Does it better preserve heart function and quality of life, without increasing pacemaker-related complications? Researchers will compare left bundle branch area pacing with conventional right ventricular pacing. A total of 642 participants will be randomly assigned to receive one of these two pacing strategies. Participants will: Have a single-chamber pacemaker implanted using either left bundle branch area pacing or conventional right ventricular pacing Undergo electrocardiograms, echocardiograms, and pacemaker checks during 2 years of follow-up Attend follow-up visits approximately 2, 12, and 24 months after implantation Be contacted by telephone approximately 6 and 18 months after implantation Complete questionnaires about their health and quality of life at the beginning and end of the study

Eligibility Criteria

Inclusion Criteria: * Age ≥ 18 years and \

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View on ClinicalTrials.gov

Source: ClinicalTrials.gov (NCT07759700). StuddyBuddy aggregates publicly available trial information.