Impact of Hypoalbuminemia on Cefoperazone/Sulbactam Induced Coagulopathy in Post-Operative Surgical Patients

The goal of this observational study is to learn whether hypoalbuminemia in post surgical patients receiving cefoperazone/sulbactam therapy poses them to the risk of developing coagulopathy. It will also study that what are the other risk factors for the development of cefoperazone/sulbactam induced coagulopathy. The main questions it aims to answer are : • Does hypoalbuminemia increase the risk of cefoperazone/sulbactam coagulopathy in post operative surgical patients? * What is the incidence of cefoperazone/sulbactam induced coagulopathy in normoalbuminemic vs hypoalbuminemic patients. * Does renal function, nutritional status, dose and duration of therapy affect coagulopathy development? * What are the independent risk factors for the development of cefoperazone/sulbactam induced coagulopathy? Patients' coagulation tests will be followed during the duration of cefoperazone/sulbactam therapy to identify coagulation development.

Inclusion Criteria: * Patients \>= 18 years * Post-operative surgical patients * Receiving cefoperazone/sulbactam therapy for at least 72 hours. * Willing to give informed consent Exclusion Criteria: * Chronic liver disease * History of any inherited coagulation disorder * On anticoagulant therapy * Any massive blood loss requiring blood transfusion * Patients who have been given Vitamin K prior to the start of cefoperazone/sulbactam therapy * Pregnancy