FABP4 Response After Roux-en-Y Gastric Bypass

This retrospective observational cohort study examined serum fatty acid-binding protein 4 (FABP4) dynamics in 28 adults who underwent Roux-en-Y gastric bypass (RYGB), followed at baseline, 3 months, and 6 months. Anthropometric, metabolic, and inflammatory parameters were assessed alongside FABP4, fasting GLP-1, and PYY. Patients were classified as FABP4 responders (decrease from baseline to 6 months) or rebound/non-responders. The study investigated whether FABP4 trajectory after RYGB is associated with the magnitude of weight loss, systemic inflammation, and fasting incretin change.

Inclusion Criteria: * Adults who underwent Roux-en-Y gastric bypass (RYGB), performed by a single surgeon * Completed baseline, 3-month, and 6-month clinical and anthropometric assessments Exclusion Criteria: * Use of GLP-1 receptor agonists at any study time point * Use of insulin at any study time point * Missing 6-month FABP4 measurement (excluded from FABP4-based longitudinal/group analyses; n=1)