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NCT07776405
A Double-Blinded Study on Rapid and Sustained Pain Relief Topical Cannabidiol for Plantar Fasciitis
Conditions: Plantar Fasciitis
Sex: All
Ages: 18 Years – 85 Years
Healthy volunteers: Yes
Phase: PHASE1
Enrollment: 50
Sponsor: University of Florida
Location: University of Florida Department of Orthopaedics Gainesville Florida
Summary
This prospective, double-blinded, placebo-controlled study evaluates the efficacy of a 6000 mg transdermal CBD cream in adults with plantar fasciitis. Fifty participants will apply either CBD or placebo once daily for one month.
Eligibility Criteria
Inclusion Criteria:
* Patients aged 18-85
* Clinical diagnosis of plantar fasciitis by a qualified provider
* Symptomatic for at least four weeks with plantar heel pain consistent with plantar fascia involvement
* Baseline average pain score that meets eligibility threshold as defined in the protocol (?)
* Willing to apply assigned cream once daily and attend needed visits (?)
Exclusion Criteria:
* Special populations and consent limitations. Pregnancy, breastfeeding, prisoners, inability to provide informed consent, or inability to complete study procedures
* Contraindications to topical products or CBD. History of allergy or sensitivity to cannabinoids, excipients, or topical creams used in the study
* Confounding dermatologic conditions at the application site. Open wounds, active infection, dermatitis, ulceration, or recent burns on the heel or midfoot
* Recent or planned procedures that alter outcomes. Corticosteroid injection, platelet rich plasma, surgery, immobilization, or shockwave therapy within the protocol washout window
* Concurrent therapies that confound pain outcomes. Routine use of systemic opioids, regular use of nonsteroidal anti-inflammatory drugs beyond rescue parameters, new analgesic starts during the study, or use of other topical analgesics on the study area
Source: ClinicalTrials.gov (NCT07776405). StuddyBuddy aggregates publicly available trial information.