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Completed
NCT07784881
Deciphering the Self-antigen Specific T Cell Signature of Autoimmune Liver Diseases
Conditions: Autoimmune Hepatitis, Primary Biliary Cholangitis (PBC), Autoimmune Liver Disease, Primary Sclerosing Cholangitis (PSC)
Sex: All
Healthy volunteers: No
Enrollment: 220
Sponsor: Nantes University Hospital
Location: Nantes University Hospital Nantes
Summary
The study aims to establish the molecular signature of autoimmune self-antigen-specific T cells in AutoImmune Liver Disease (AILD)
Eligibility Criteria
Inclusion Criteria:
* Patient informed consent
* AIH with no previous treatment whose diagnosis is validated by at least 2 of the following criteria:
* ALT\>2N or IgG\>1.1N
* Presence of autoantibodies : ANA (antinuclear), ML (anti-smooth muscle), SLA (anti-soluble liver antigen), LKM1 (anti-endoplasmic reticulum), LC1 (anti-liver cytosol)
* Presence of interface hepatitis on biopsy
Exclusion Criteria:
* HIV positive
* HBV infection Positive
* HCV serology positive and PCR positive
Source: ClinicalTrials.gov (NCT07784881). StuddyBuddy aggregates publicly available trial information.
