Effects of Supervised Aerobic Exercise on Biomarkers, Physical Function, and Quality of Life in Breast Cancer Survivors

This study evaluates the effects of a 12-week supervised aerobic exercise program in women who have completed primary treatment for early-stage breast cancer and are in remission. The study aims to determine whether regular aerobic exercise is associated with changes in physical function, quality of life, cognitive function, and selected blood biomarkers. Participants take part in a supervised aerobic exercise program for 12 weeks. Assessments are performed before the program, at week 6, and at week 12. These assessments include a walking test, questionnaires about quality of life and cognitive function, and blood sampling. Blood samples are used to measure GDF15, NF-κB p105, and visfatin. Changes in these measures over the 12-week exercise period are evaluated together with changes in functional capacity and patient-reported outcomes.

Inclusion Criteria: Women aged 18-65 years Histologically confirmed stage I-II nonmetastatic breast cancer Completion of indicated primary cancer treatment at least 6 months before enrollment and currently in remission Ongoing endocrine therapy permitted No participation in regular structured physical activity during the preceding 6 months Medically eligible to participate in aerobic exercise and study assessments Physician clearance to participate in aerobic exercise Residing in or near the city where the study was conducted Provision of written informed consent Exclusion Criteria: Metastatic breast cancer Clinically significant cardiovascular, respiratory, neurological, or musculoskeletal conditions that could limit safe participation in aerobic exercise Clinically significant lymphedema Pregnancy or breastfeeding Use within the preceding 8 weeks of antidepressants, anxiolytics, antipsychotics, chronic analgesics, or sedatives considered likely to influence cognitive assessments or biological outcomes