Postprandial Glucose Kinetics After Carbohydrate Restriction

Conditions: Prediabetes, Obesity & Overweight, Diet Interventions, Carbohydrate Metabolism

Sex: All

Ages: 18 Years – 65 Years

Healthy volunteers: No

Phase: NA

Enrollment: 29

Sponsor: Azienda Ospedaliero, Universitaria Pisana

Location: Laboratory of Metabolism, Nutrition and Atherosclerosis, University of Pisa Pisa PI

Summary

The goal of this study is to test whether a low-carbohydrate diet (LCD), comparred with a Mediterranean diet (MED) producing similar weight loss, differentially affects fasting and postprandial glucose metabolism in individuals with overweight and dysglycemia. The main questions it aims to answer are: * Is oral glucose absorption delayed or reduced after chronic carbohydrate restriction? * Is insulin sensitivity differentially affected? Participants will follow 4 weeks of LCD and 4 weeks of MED, in a random order, separated by a 4-week washout. After each intervention, participants will undergo a dual-tracer 75-g oral glucose tolerance test.

Eligibility Criteria

Inclusion Criteria: * both females and males * age 18-65 years * BMI 25-40 kg/m2 * impaired glucose regulation (defined as fasting plasma glucose 5.6-6.9 mmol/L, 1-h plasma glucose ≥8.6 mmol/L, 2-h plasma glucose 7.8-11.0 mmol/L, or HbA1c 39-47 mmol/mol) Exclusion Criteria: * Diabetes mellitus * Chronic kidney disease * Heart failure * Severe liver disease * Medications known to interfere with carbohydrate metabolism or intestinal nutrient absorption * Metabolic surgery

Interested in this study? View the official listing for contact and enrollment details.

View on ClinicalTrials.gov

Source: ClinicalTrials.gov (NCT07802275). StuddyBuddy aggregates publicly available trial information.