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Completed
NCT07802613
ALDH2 rs671, Alcohol Use, and Health Education in University Students
Conditions: Alcohol Intolerance, Alcohol Drinking in College, Aldehyde Dehydrogenase-2 (ALDH2) Deficiency
Sex: All
Ages: 18 Years – 65 Years
Healthy volunteers: Yes
Phase: NA
Enrollment: 622
Sponsor: National Taiwan University Hospital
Location: National Taiwan University Taipei
Summary
Alcohol intolerance is common in East Asian populations and is strongly influenced by the rs671 variant in the ALDH2 gene. This study examined the associations of ALDH2 genotype with drinking behavior and alcohol-related reactions among Taiwanese university students. Participants with previous alcohol exposure underwent rs671 genotyping and received their individual genotype results together with the same standardized health education materials about alcohol intolerance and related health risks. Drinking behavior, knowledge, and attitudes were assessed before and one month after the intervention. The study also evaluated whether facial flushing and rapid heartbeat could help identify ALDH2 deficiency. Changes over the one-month period were evaluated overall and by genotype group.
Eligibility Criteria
Inclusion Criteria:
* Currently enrolled as a student at National Taiwan University
* Aged 18 to 65 years
Exclusion Criteria:
* None
Source: ClinicalTrials.gov (NCT07802613). StuddyBuddy aggregates publicly available trial information.
