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Completed NCT07805837

Comparative Immunologic Mechanisms and Microbiome Interactions Following Different Influenza Vaccine Formulations in Older Adults

Conditions: Influenza, Influenza Vaccines, Microbiome, Immune Response

Sex: All

Ages: 65 Years – N/A

Healthy volunteers: Yes

Phase: PHASE4

Enrollment: 121

Sponsor: Korea University Guro Hospital

Location: Korea University Guro Hospital Seoul Seoul

Summary

This prospective, randomized, open-label clinical study aims to evaluate the immunogenicity and underlying immune mechanisms of different influenza vaccine formulations in adults aged ≥65 years. Additionally, the study investigates the role of the gut microbiome in modulating vaccine-induced immune responses and durability.

Eligibility Criteria

Inclusion Criteria: * Age ≥65 years * Able and willing to provide informed consent Exclusion Criteria: * Influenza vaccination within the past 6 months * Laboratory-confirmed influenza infection within the past 6 months * Immunocompromised status * Uncontrolled chronic medical conditions

Interested in this study? View the official listing for contact and enrollment details.

View on ClinicalTrials.gov

Source: ClinicalTrials.gov (NCT07805837). StuddyBuddy aggregates publicly available trial information.