A Trial in Healthy Participants to Assess Drug Interaction Potential of BGB-43395

Conditions: Healthy Adult Participants

Sex: All

Ages: 18 Years – 65 Years

Healthy volunteers: Yes

Phase: PHASE1

Enrollment: 24

Sponsor: BeOne Medicines

Location: Fortrea CRU Dallas Texas

Summary

This study will enroll healthy participants to evaluate whether BGB-43395 interacts with other drugs, including midazolam, celecoxib, dabigatran, and rosuvastatin.

Eligibility Criteria

Inclusion Criteria: * Body mass index between 18.0 and 32.0 kg/m\^2, inclusive. * In good health, as determined by no clinically significant findings from medical history, 12-lead electrocardiogram and vital signs measurements, and clinical laboratory assessments. * Participants must not be pregnant or lactating and must agree to use contraception. Exclusion Criteria: * Significant history or clinical manifestation of any metabolic, allergic, dermatological, hepatic, renal, hematological, pulmonary, cardiovascular, gastrointestinal, neurological, respiratory, endocrine, or psychiatric disorder, as determined by the investigator * History of stomach or intestinal surgery or resection that would potentially alter absorption and/or excretion of orally administered drugs * Confirmed systolic blood pressure \>140 or \90 or \100 or \

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View on ClinicalTrials.gov

Source: ClinicalTrials.gov (NCT07820891). StuddyBuddy aggregates publicly available trial information.