Frailty and Outcomes in Critically Ill Patients Receiving CRRT

This nationwide observational cohort study will investigate the association between frailty, chronological age, and clinical outcomes in critically ill patients receiving continuous renal replacement therapy (CRRT) in Sweden. Using data from the Swedish Intensive Care Registry, the study will assess whether the Clinical Frailty Scale (CFS) and other measures of comorbidity and illness severity provide prognostic information beyond chronological age. Outcomes will include 30-day mortality, intensive care unit length of stay, and mortality at 60, 90, and 365 days following intensive care unit (ICU) admission. The study aims to contribute to more individualized assessment of critically ill patients who may require CRRT.

Inclusion criteria: * Patients aged 18 years or older. * Patients treated in an intensive care unit in Sweden. * Patients receiving continuous renal replacement therapy (CRRT) during the ICU stay. * ICU admissions occurring between January 1, 2012, and December 31, 2026, subject to confirmation of the final study period. Exclusion Criteria: * Age below 18 years. * No treatment with CRRT during the ICU stay. Concealed or temporary personal identity number. Invalid registration date of death. Emigration within 30 days after ICU admission. Missing SAPS3 score.