Resistance Training and Creatine Supplementation for Head and Neck Cancer

The study will examine a 10-week resistance training program, with or without creatine monohydrate supplementation, in adult survivors of head and neck cancer. Participants will undergo screening and complete study assessments before and after the training period and at a follow-up evaluation. The study will evaluate feasibility, safety, body composition, physical function, cancer-related fatigue, quality of life, and symptom burden in this population.

Inclusion Criteria: 1. Age 18 years or older. 2. Diagnosis of head and neck cancer (AJCC stages I-IV). 3. Completed curative-intent primary treatment, including surgery, radiation, chemotherapy, or combination treatment, within the past 1 to 3 months. 4. Clearance to engage in moderate-intensity exercise based on the American College of Sports Medicine (ACSM) Preparticipation Screening Guidelines. 5. Willingness and ability to participate in both in-person and/or virtual supervised exercise sessions. 6. Willingness to adhere to the supplementation regimen throughout the study. 7. English-speaking and able to understand study instructions and complete questionnaires. 8. Access to internet for remotely supervised exercise sessions. 9. Availability for the full 10-week intervention and post-intervention assessments. Exclusion Criteria: 1. Current participation in structured resistance training 2 or more days per week within the past 6 months. 2. Cognitive, psychiatric, or neurologic conditions that would impair ability to consent or adhere to study procedures. 3. Pre-existing renal impairment. 4. Current use of creatine supplements, defined as consistently taking creatine more than 2 days per week for the past 6 months.