Metabolic and Hormonal Parameters in Women With Polyendocrine Metabolic Ovarian Syndrome

Conditions: Polycystic Ovary Syndrome, Polycystic Ovary Syndrome (PCOS) Women, Fetuin-A, Serum Biomarkers, Insulin Resistance

Sex: Female

Ages: 18 Years – 35 Years

Healthy volunteers: Yes

Enrollment: 80

Sponsor: Istinye University

Summary

Polyendocrine Metabolic Ovarian Syndrome (PMOS) is a common endocrine and metabolic disorder associated with insulin resistance, hyperandrogenism, and an increased risk of long-term metabolic complications. Fetuin-A and resistin are adipokines implicated in insulin resistance and chronic inflammation and may serve as potential biomarkers for metabolic dysfunction in women with PMOS. This prospective observational case-control study aims to compare serum and salivary Fetuin-A and resistin levels between women with PMOS and healthy controls. The study will evaluate the correlation between serum and salivary biomarker concentrations and investigate their associations with insulin resistance, lipid profile, and hormonal parameters. The findings may help determine whether salivary measurements can serve as reliable non-invasive biomarkers for the diagnosis and metabolic assessment of PMOS.

Eligibility Criteria

Inclusion Criteria: PMOS Group: * Female, aged 18-35 years * Diagnosis of Polyendocrine Metabolic Ovarian Syndrome (PMOS) according to the Rotterdam criteria * BMI \

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View on ClinicalTrials.gov

Source: ClinicalTrials.gov (NCT07844785). StuddyBuddy aggregates publicly available trial information.