Anti-Wrinkle Efficacy of a Syringic Acid-Containing Emulsion

This randomized, double-blind, split-face controlled study was conducted to evaluate the anti-wrinkle efficacy and safety of a Syringic acid-containing emulsion in healthy female subjects. The test product was an emulsion containing 2% Synox, a Syringic acid-containing ingredient, while the control product was an emulsion without Synox. Participants applied the test and control products to opposite sides of the face according to random allocation for 12 weeks. Skin wrinkle-related parameters were evaluated at baseline and after 4, 8, and 12 weeks of product use using visual assessment, replica-based instrumental measurement, and subject questionnaires. Skin safety was monitored throughout the study period.

Inclusion Criteria: 1. Adults aged 30 to 65 years with facial wrinkles at the test site according to investigator assessment. 2. Healthy subjects without acute or chronic systemic diseases, including skin diseases. 3. Subjects who voluntarily agreed to participate after receiving sufficient explanation of the study purpose and procedures and provided written informed consent. 4. Subjects who were able to comply with study procedures and follow-up visits. Exclusion Criteria: 1. Subjects who were pregnant, breastfeeding, or planning pregnancy within 6 months. 2. Subjects who had used topical products containing steroids for treatment of skin diseases for more than one month. 3. Subjects who participated in similar clinical studies within 6 months. 4. Subjects with sensitive or hypersensitive skin. 5. Subjects with abnormal skin conditions at the test site, including moles, warts, or telangiectasia. 6. Subjects who had used similar cosmetics or medicines within 3 months before study initiation. 7. Subjects who received or planned cosmetic procedures (e.g., skin peeling, Botox, or other dermatological treatments) within 6 months. 8. Subjects with chronic wasting diseases or systemic diseases. 9. Subjects considered unsuitable for participation by the investigator.