← Back to all trials
Recruiting
NCT07851259
A Study to Assess the Efficacy and Safety of RO7965032 in Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration
Conditions: Geographic Atrophy Secondary to Age-Related Macular Degeneration
Sex: All
Ages: 50 Years – N/A
Healthy volunteers: No
Phase: PHASE2
Enrollment: 321
Sponsor: Genentech, Inc.
Location: Bay Area Retina Specialists Medical Group - Vestrum - PPDS Walnut Creek California
Summary
This study will assess the safety and efficacy of RO7965032 to address a significant unmet medical need in participants with geographic atrophy (GA) secondary to age-related macular degeneration (AMD)
Eligibility Criteria
Inclusion Criteria:
Ocular Inclusion Criteria for the Study Eye
* BCVA score of \>= 35 letters using the ETDRS VA chart at a starting distance of 4 meters
* Lesions may be either extrafoveal or subfoveal
Ocular Inclusion Criteria for Both Eyes
* Sufficiently clear ocular media, adequate pupillary dilation, and fixation to permit quality fundus imaging
* Well-demarcated GA secondary to AMD
Exclusion Criteria:
General Exclusion Criteria - History of hypersensitivity, a severe allergic reaction or anaphylactic reaction to any component of the investigational drug injection
Ocular Exclusion Criteria for the Study Eye
* History of diabetic macular edema (DME), retinal vein occlusion, corneal transplant, retinal detachment, Stage 3 or 4 macular hole, optic neuropathy, or retinal dystrophy
* Current or prior history of central serous retinopathy
* Aphakia or absence of the posterior capsule in the study eye
Ocular Exclusion Criteria for the Non-Study Eye
\- Non-functioning non-study eye defined as either BCVA of hand motion or worse or no physical presence of non-study eye (i.e., monocular)
Ocular Exclusion Criteria for Either Eye
* Proliferative diabetic retinopathy
* History of recurrent infectious or inflammatory ocular disease
* Current or prior history of choroidal neovascularization (CNV) in either eye
* Active, infectious conjunctivitis, keratitis, scleritis, or endophthalmitis in either eye
Other protocol-defined inclusion/exclusion criteria may apply
Source: ClinicalTrials.gov (NCT07851259). StuddyBuddy aggregates publicly available trial information.