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Recruiting NCT07851259

A Study to Assess the Efficacy and Safety of RO7965032 in Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration

Conditions: Geographic Atrophy Secondary to Age-Related Macular Degeneration

Sex: All
Ages: 50 Years – N/A
Healthy volunteers: No
Phase: PHASE2
Enrollment: 321
Sponsor: Genentech, Inc.

Location: Bay Area Retina Specialists Medical Group - Vestrum - PPDS Walnut Creek California

Summary

This study will assess the safety and efficacy of RO7965032 to address a significant unmet medical need in participants with geographic atrophy (GA) secondary to age-related macular degeneration (AMD)

Eligibility Criteria

Inclusion Criteria: Ocular Inclusion Criteria for the Study Eye * BCVA score of \>= 35 letters using the ETDRS VA chart at a starting distance of 4 meters * Lesions may be either extrafoveal or subfoveal Ocular Inclusion Criteria for Both Eyes * Sufficiently clear ocular media, adequate pupillary dilation, and fixation to permit quality fundus imaging * Well-demarcated GA secondary to AMD Exclusion Criteria: General Exclusion Criteria - History of hypersensitivity, a severe allergic reaction or anaphylactic reaction to any component of the investigational drug injection Ocular Exclusion Criteria for the Study Eye * History of diabetic macular edema (DME), retinal vein occlusion, corneal transplant, retinal detachment, Stage 3 or 4 macular hole, optic neuropathy, or retinal dystrophy * Current or prior history of central serous retinopathy * Aphakia or absence of the posterior capsule in the study eye Ocular Exclusion Criteria for the Non-Study Eye \- Non-functioning non-study eye defined as either BCVA of hand motion or worse or no physical presence of non-study eye (i.e., monocular) Ocular Exclusion Criteria for Either Eye * Proliferative diabetic retinopathy * History of recurrent infectious or inflammatory ocular disease * Current or prior history of choroidal neovascularization (CNV) in either eye * Active, infectious conjunctivitis, keratitis, scleritis, or endophthalmitis in either eye Other protocol-defined inclusion/exclusion criteria may apply

Interested in this study? View the official listing for contact and enrollment details.

View on ClinicalTrials.gov

Source: ClinicalTrials.gov (NCT07851259). StuddyBuddy aggregates publicly available trial information.