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NCT07855458
ESA Hyporesponsiveness in Hemodialysis Patients
Conditions: Chronic Kidney Disease (CKD), Hemodialysis Complication, Anemia
Sex: All
Ages: 18 Years – N/A
Healthy volunteers: No
Enrollment: 200
Sponsor: Assiut University
Summary
This prospective cohort study aims to evaluate the development, persistence, and recovery of erythropoiesis-stimulating agent (ESA) hyporesponsiveness among patients receiving maintenance hemodialysis.
Eligibility Criteria
Inclusion Criteria:
* Age ≥18 years.
* ESRD/CKD G5D receiving maintenance hemodialysis.
* Hemodialysis ≥3 months before enrollment.
* Receiving ESA therapy for anemia.
* Expected to remain on hemodialysis during the study period.
* Baseline Hb and ESA dose available.
Exclusion Criteria:
* Active malignancy.
* Hematological malignancy.
* Known hemoglobinopathy causing anemia.
* Recent blood transfusion, e.g. within 3 months before enrollment.
* Recent major surgery.
* Active major bleeding.
* Pregnancy.
* Recent kidney transplantation.
* Known pure red-cell aplasia.
* Incomplete clinical or laboratory follow-up
Source: ClinicalTrials.gov (NCT07855458). StuddyBuddy aggregates publicly available trial information.
