Innovative Approaches to Identify Causative Genetic Variants in Patients With Unexplained Bleeding Disorders

Creation of an Italian network for unexplained bleeding disorders, using integrated multi-omics approaches to improve diagnosis, optimize patient management, and identify novel therapeutic targets.

Inclusion Criteria: * Diagnosis of an unexplained bleeding disorder (UBD) * Willingness to participate in the study and provision of written informed consent * Ability to provide the blood sample required for the study analyses * Male or female participants aged 3 years or older (to avoid collecting large blood volumes from newborns) * ISTH-BAT score \>4 in adult males, \>6 in adult females, and \>3 in children Exclusion Criteria: * Age below 3 years * History of organ transplantation * Any condition that may impair the participant's ability to comply with the study protocol requirements * Inability to obtain a blood sample (e.g., poor or limited venous access) * Diagnosis of an inherited or acquired bleeding disorder