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NCT07870187
Effects of Cannabidiol (CBD) on a Fixed Dose of Delta-9-tetrahydrocannabinol (THC)
Conditions: Cannabis Intoxication
Sex: All
Ages: 21 Years – N/A
Healthy volunteers: Yes
Phase: PHASE1
Enrollment: 70
Sponsor: Johns Hopkins University
Location: Johns Hopkins University Baltimore Maryland
Summary
This study will evaluate the subjective and behavioral effects of cannabis products containing delta-9-tetrahydrocannabinol and cannabidiol
Eligibility Criteria
Inclusion Criteria:
* at least 21 years old;
* be in good general health based on screening procedures (e.g., physical exam, EKG, blood testing, psychiatric evaluation);
* have vital signs in normal range;
* have not donated blood in past 30 days;
* not be pregnant (assessed via blood serum at screening and urinalysis before each study session) or breast feeding (women only);
* have a body mass index (BMI) in the range of 18 to 36 kg/m\^2;
* report using cannabis in the last 3 years, but not in the past month;
* negative urine test for illicit drug use (including THC) and negative breath alcohol test (0% breath alcohol concentration) at screening and before study sessions.
Exclusion Criteria:
* psychoactive drug use (aside from nicotine, alcohol, or caffeine) in past month;
* current use of over the counter (OTC) drugs, supplements/vitamins, or prescription medications that, in the opinion of the investigator or medical staff, will impact the participant's safety or pharmacokinetics (PK) of the study drugs;
* history of or current evidence of significant medical condition;
* evidence of current psychiatric condition (based on MINI);
* been in treatment previously for cannabis use disorder;
* liver function tests more than 2x normal range;
* enrollment in another clinical trial or receiving of any drug as part of research within past 30 days;
* epilepsy or a history of seizures
Source: ClinicalTrials.gov (NCT07870187). StuddyBuddy aggregates publicly available trial information.