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NCT07873164
Vagal Auricular Stimulation for Motion Sickness
Conditions: Chronic Nausea
Sex: All
Ages: 18 Years – 65 Years
Healthy volunteers: Yes
Phase: NA
Enrollment: 115
Sponsor: Spaulding Rehabilitation Hospital
Location: Spaulding Rehabilitation Hospital, 300 First Avenue Boston Massachusetts
Summary
This study aims to understand the mechanisms underlying nausea response in the brain stem, and the effect of vagal nerve stimulation on nausea.
Eligibility Criteria
Inclusion Criteria:
* Age 18-65 years old (inclusive)
* Ability to give written consent and participate in behavioral intervention in English
* Avoidance of alcohol, nicotine, and caffeine for 24 hours prior to study session
* Motion Sickness Susceptibility Questionnaire (MSSQ) percentile score \> 60.
* Adequate visual, hearing, cognitive, and physical ability
Exclusion Criteria:
* Chronic nausea due to medications or gastrointestinal conditions
* Prior or current history of seizures
* Severe autonomic dysfunction
* No active clinical acupuncture therapy
* History of arrhythmias
* Endorses any contraindications to MRI
* Body weight of 450 lbs or greater or BMI of 32 kg/m2 or greater (limit of MRI table)
* History any serious medical condition (e.g., cancer)
* Pregnancy/breastfeeding within the last 8 weeks
* Uncontrolled diabetes (indicated by HbA1c ³ 7%) by chart
* Narcotic analgesics greater than three days per week
* Illicit drugs or opioid usage
* Cannabinoid use greater than three days per week
* Intellectual disability by history
* Illiteracy
* Inability to provide informed consent
* Any other condition interfering with study requirements, according to the investigator
Source: ClinicalTrials.gov (NCT07873164). StuddyBuddy aggregates publicly available trial information.