← Back to all trials
Completed
NCT07873385
Evaluation of MTHFR Gene Polymorphism and Periodontal Clinical Parameters in Healthy, Hypertensive, and Periodontitis Individuals
Conditions: Hypertension, Periodontitis
Sex: All
Ages: 18 Years – N/A
Healthy volunteers: Yes
Enrollment: 200
Sponsor: Akdeniz University
Location: Akdeniz University Faculty of Dentistry, Department of Periodontology Antalya Antalya
Summary
This observational study aims to evaluate the relationship between MTHFR gene polymorphisms and periodontal clinical findings in healthy individuals, individuals with hypertension, individuals with periodontitis, and individuals with both hypertension and periodontitis. A total of 200 participants will be included in four groups of 50 participants each. Periodontal clinical measurements, including plaque index, gingival index, bleeding on probing, probing depth, and clinical attachment level, will be recorded. Venous blood samples will be collected for DNA isolation and analysis of MTHFR gene polymorphisms. The study will investigate whether MTHFR gene polymorphisms are associated with periodontal clinical parameters and hypertension.
Eligibility Criteria
Inclusion Criteria:
* Age 18 years or older.
* Nonsmokers.
* No periodontal treatment within the previous 6 months.
* No systemic disease affecting periodontal health other than hypertension.
* No tuberculosis, hepatitis, or AIDS.
* Not pregnant.
Exclusion Criteria:
Inclusion Criteria:
* Age 18 years or older.
* Nonsmokers.
* No periodontal treatment within the previous 6 months.
* No systemic disease affecting periodontal health other than hypertension.
* No tuberculosis, hepatitis, or AIDS.
* Not pregnant.
Exclusion Criteria:
none
Source: ClinicalTrials.gov (NCT07873385). StuddyBuddy aggregates publicly available trial information.
