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NCT07874945
Peripheral Vascular Effects of Insulin in Obesity
Conditions: Obesity (BMI>30), Insulin Resistance
Sex: All
Ages: 18 Years – 65 Years
Healthy volunteers: Yes
Phase: EARLY_PHASE1
Enrollment: 64
Sponsor: University of Missouri-Columbia
Summary
Successful completion of this project will advance our understanding of the role sympathetic nervous system overactivity plays in driving skeletal muscle malperfusion during hyperinsulinemia and consequently impaired glucose uptake in obesity.
Eligibility Criteria
Inclusion Criteria:
\- 18 to 65 years of age
Individuals with obesity and comorbid IR
* BMI 30-45 kg/m2
* Waist circumference ≥102 cm (men) or ≥88 cm (women)
* HOMA-IR ≥2.5
Healthy normal weight adults
* BMI 18-25 kg/m2
* Waist circumference \10% within the last 6 months
* Sensitivity to lidocaine
* Increased risk of bleeding, pro-coagulant disorders, clotting disorders, anticoagulation therapy
* History of hypersensitivity to nitrates
Source: ClinicalTrials.gov (NCT07874945). StuddyBuddy aggregates publicly available trial information.
