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Completed
NCT07876713
Acetazolamide to Reduce Spinal Fluid Leaks After Spine Surgery.
Conditions: Cerebrospinal Fluid Leak, Dural Tear, Incidental Durotomy
Sex: All
Ages: 18 Years – N/A
Healthy volunteers: No
Phase: PHASE4
Enrollment: 26
Sponsor: Ain Shams University
Location: Ain Shams University Hospitals. Cairo
Summary
This study aims to evaluate the effectiveness and safety of acetazolamide in helping patients recover from accidental dural tears during spine surgery. Adding acetazolamide to standard post-surgery care is hypothesized to be a safe and effective way to reduce spinal fluid leakage, ease headaches, and speed up recovery.
Eligibility Criteria
Inclusion Criteria:
* Adults aged 18 years and older.
* Patients who sustained an incidental/iatrogenic dural tear during degenerative lumbar spine surgery.
* Eligible to receive oral acetazolamide safely without contraindications.
Exclusion Criteria:
* Known hypersensitivity or allergic reaction to acetazolamide or other sulfonamide derivatives.
* Significant renal impairment (creatinine clearance \< 50 mL/min) or severe hepatic disease.
* Significant pre-existing cardiovascular conditions.
* Pregnant or breastfeeding females.
Source: ClinicalTrials.gov (NCT07876713). StuddyBuddy aggregates publicly available trial information.
