Postoperative Pain Trajectories After Endometriosis Surgery

The pain associated with endometriosis reflects a multifactorial pathophysiology combining peripheral nociception, central sensitisation and psychosocial factors. Although surgery is an integral part of treatment, a significant proportion of patients experience persistent pain several months after the procedure. To date, postoperative pain trajectories after endometriosis surgery remain poorly characterised, and there are no reliable predictors of chronic postoperative pain (CPP). This prospective, single-centre, longitudinal study aims to identify distinct postoperative pain trajectories and to assess whether perioperative quantitative sensory testing can predict the development of chronic postoperative pain at 3 and 6 months. Patients will undergo perioperative mechanical and pressure tests, including assessment of temporal summation and pressure pain thresholds, combined with validated measures of patient- reported outcomes. Follow-up assessments will be conducted on day 2, day 14, 1 month, 3 months, and 6 months after surgery to capture the dynamic evolution of pain, quality of life, fatigue, sexual function, and central sensitisation symptoms.

Inclusion Criteria: * Age ≥ 18 years * Imaging-confirmed endometriosis * Scheduled surgical treatment for endometriosis * Affiliation to the French Social Security system * Written informed consent obtained Exclusion Criteria: * Patients under legal protection (guardians or curators) * History of psychiatric disorders * Neurodegenerative diseases * Inability to self-assess pain using a numerical rating scale * Non-French-speaking patients * Pregnancy or breastfeeding * Refusal to participate