Platelet Rich Plasma Versus Mitomycin C Injection Following Visual Internal Urethrotomy in Urethral Stricture

this is a randomized clinical trial that was conducted at Ain Shams University to compare the effectiveness and safety of two different substances injected after visual internal urethrotomy for treating urethral stricture in adult men. Fifty male patients with short urethral strictures were randomly divided into two equal groups, with one group receiving a mitomycin C injection and the other receiving a platelet-rich plasma injection at the site of the urethrotomy. Patients were followed for six months, with evaluations at three and six months that included symptom scores, quality of life assessments, urine flow measurements, post-void residual urine volume, and recurrence rates.

Inclusion Criteria: * Patients who had urethral stricture and had not undergone visual internal urethrotomy in the past. * Stricture length equal to or less than 1.5 cm. * Adult males. Exclusion Criteria: * Documented or suspicious prostate cancer. * History of hypospadias repair and urethroplasty. * Patients who had neurogenic bladder. * Untreated urinary tract infection.