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NCT07884058
IGOB131 As A GLP-1 Modulator For Metabolic Disorders In Adults With Obesity
Conditions: Obesity & Overweight
Sex: All
Ages: 18 Years – 65 Years
Healthy volunteers: No
Phase: PHASE2
Enrollment: 80
Sponsor: University of Yaounde 1
Summary
This clinical trial will investigate the effect of standardized Irvingia gabonensis extract (IGOB131) on GLP-1 dynamics, DPP-4 activity, metabolic parameters, and inflammatory markers in adults with obesity.
The study will compare IGOB131 to a placebo to find out if it exerts any significant metabolic benefits through GLP-1 and DPP-4 modulation, and the reduction of adiposity and systemic inflammation.
Participants will:
Take IGOB131 or a placebo every day for 16 weeks Visit the clinic once every 4 weeks for checkups and tests
Eligibility Criteria
Inclusion Criteria:
* Males and females with BMI between 25 and 34 kg/m²
* Participants aged 18 to 65 years old
* Participants willing to comply with the study protocol
Exclusion Criteria:
* Participants younger than 18 years or older than 65 years
* Participants not available for the study period
* Morbid obesity (BMI \> 34.9 kg/m²)
* Diabetes mellitus requiring daily insulin management
* Pregnancy or breastfeeding
* Active infection
* Systemic diseases, including HIV/AIDS, Active hepatitis, Clinical signs of active malignancy within the past 5 years
* Use of any medication or natural health product that might affect the parameters of interest in this study
Source: ClinicalTrials.gov (NCT07884058). StuddyBuddy aggregates publicly available trial information.