Effects of Tart Cherry and Aronia Extract Supplementation on Selected Physiological Parameters in Endurance-Trained Men

This study will evaluate the effects of four weeks of oral supplementation with a double-standardized tart cherry (Prunus cerasus) and aronia (Aronia melanocarpa) extract on cardiovascular regulation and exercise performance in healthy endurance-trained men aged 40 to 75 years. In a randomized crossover design, 25 participants will receive CHG SPORT and placebo for four weeks each, separated by a four-week washout period. Assessments will include resting cardiovascular and respiratory measurements, cardiovascular and ventilatory responses to transient hypoxia, flow-mediated dilation, skin advanced glycation end products, cardiopulmonary exercise testing, 24-hour ambulatory blood pressure, and blood biomarkers. The study will determine whether CHG SPORT supplementation produces changes in selected cardiovascular and exercise-performance measures compared with placebo.

Inclusion Criteria: * Male sex * Age 40 to 75 years * Active participation in endurance sports, including running, cycling, or other - endurance disciplines, with at least two training sessions per week Exclusion Criteria: * Cardiovascular disease * Diabetes mellitus * Liver or gastrointestinal disease * Cancer * Inflammatory disease * Chronic use of anti-inflammatory medications * Alcohol or drug abuse * Current tobacco smoking * Autoimmune disease * Acute infection within two months before planned study participation * Use of dietary supplements containing high amounts of polyphenols within two months before planned study participation * Lack of written informed consent