Methylation Analyses for Gynaecological Research Through Home-based Self-sampling

The goal of the MARGOT study is to collect self-samples, such as first-void urine and vaginal samples, from people without cancer and compare them with samples from people with gynecological (pre-)cancers collected in other studies, to better understand the differences in biological markers present in these samples between these two groups.

Inclusion Criteria: * Individuals having female genital organs, regardless of their gender identity * Participant is 18 years or older at the time of signing the informed consent form * Participant must be able to understand the (Dutch) information consent form and what the study is about * Participant must be able to provide written informed consent and take urine- and vaginal self-samples * Individual has a Belgian nationality Exclusion Criteria: * Individuals that underwent hysterectomy or ovariectomy * Pregnant individuals or 6 months post-partum * (History of) (pre)cancer, or an ongoing diagnostic work-up or treatment for oncological concerns * Unable to give informed consent or to take urine- or vaginal self-samples * Participation in another interventional study. However, participation in another low-interventional or observational study is allowed * Individuals who have (a history) of postmenopausal bleeding