Asthma and Primary Arterial Hypertension: an Inflammatory Link?

A low-intervention, prospective, experimental study will be conducted with the overall aim of assessing the inflammatory, functional and clinical differences between patients with asthma and those with asthma and hypertension, in order to improve our understanding of asthma and its comorbidities

Inclusion Criteria: * Age ≥18 and ≤85 years; * Diagnosis of moderate/severe asthma according to current Global Initiative for Asthma (GINA) guidelines * Diagnosis of moderate/severe asthma according to current GINA guidelines and primary arterial hypertension according to current European Society of Cardiology/European Society of Hypertension (ESC/ESH) guidelines * Patients able to collaborate in the required procedures; * Signed informed consent. Exclusion Criteria: * History of asthma exacerbation requiring changing of pharmacological treatment in the previous month. * Active smoking status or ex-smoker with Pack/Year major than 10; * BMI major than 30 Kg/m2; * Pregnancy; * Diagnosis of concomitant Chronic Obstructive Pulmonary Disease (COPD); Obstructive Sleep Apnoea Syndrome (OSA); Clinically significant bronchiectasis; Allergic bronchopulmonary aspergillosis (ABPA); Atopic dermatitis; * Diagnosis of concomitant Autoimmune Diseases; History of Human Immunodeficiency Virus (HIV), Hepatitis B Virus (HBV), or (Hepatitis C Virus)HCV ; * Active significant infection * Malignancy, current or within the past 5 years. Suspected malignancy or undefined neoplasms; * Cognitive impairment; * History of clinically significant chronic heart diseases;