Effect of Ultrasonic and Diode Laser Activated Irrigation on Postoperative Pain Following Root Canal Treatment

The study is designed to determine whether activation of the irrigant using ultrasonic or diode laser technology can reduce postoperative pain and influence Substance P levels compared with conventional needle irrigation. The findings may contribute to establishing evidence-based irrigation activation protocols for improving patient comfort following root canal treatment.

Inclusion 1. Healthy patients ranging between 18 and 65 years in age . 2. Patients that experienced moderate-to-severe pain (4-10)-represented on a visual analogue scale (VAS). 3. Having a mandibular single rooted premolar tooth with vital pulp. 4. Having the symptoms of symptomatic irreversible pulpitis and apical periodontitis. Exclusion 1. Patients who were pregnant or lactating. 2. Patients taking analgesic or anti-inflammatory drugs within the least 12 hours. 3. Teeth with calcified root canals, resorptions. 4. Previously root canal treated. 5. severe damage and associated traumatic occlusion. 6. Teeth with open apices. 7. Presence of periodontal pockets \>3 mm in the affected tooth.