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Recruiting NCT07914920

Postprandial Hypotension, Frailty and Post-Induction Hypotension in Older Patients Undergoing Noncardiac Surgery

Conditions: Post-induction Hypotension (PIH), Postprandial Hypotension, Frailty

Sex: All
Ages: 65 Years – N/A
Healthy volunteers: No
Enrollment: 200
Sponsor: Konya City Hospital

Location: Konya City Hospital Konya Konya

Summary

The goal of this observational study is to learn whether a drop in blood pressure after a meal (postprandial hypotension) and frailty are linked to low blood pressure after the start of general anesthesia (post-induction hypotension) in adults aged 65 years and older having planned non-heart surgery. The main questions it aims to answer are: * Do patients whose blood pressure drops after a meal have low blood pressure in the first 20 minutes after the start of anesthesia, or until surgery begins, more often than patients whose blood pressure does not drop? * Is frailty related to blood pressure drops after a meal and after the start of anesthesia? * Is the size of the blood pressure drop after a meal related to the size of the blood pressure drop and the need for blood pressure-raising medicines after the start of anesthesia? Researchers will compare patients with and without postprandial hypotension to see if post-induction hypotension is more common in patients with postprandial hypotension. Researchers will also look at whether patients need intensive care unit admission after surgery and how long they stay in the intensive care unit and in the hospital. Participants will: * Have their blood pressure and heart rate measured with an automatic arm cuff before and up to 2 hours after their usual hospital evening meal on the day before surgery * Answer short questions and complete simple tests for frailty (Edmonton Frail Scale) on the day before surgery * Answer six short questions about anxiety (Amsterdam Preoperative Anxiety and Information Scale) on the morning of surgery * Receive their usual anesthesia care; blood pressure values recorded during routine monitoring in the first 20 minutes after the start of anesthesia, or until surgery begins, will be collected for the study * Have information about intensive care unit admission and length of hospital stay collected from their medical records until discharge

Eligibility Criteria

Inclusion Criteria: * Age 65 years or older * Scheduled for elective noncardiac surgery * Scheduled to receive general anesthesia * ASA physical status I-III * Sufficient cognitive and communication ability to complete the Edmonton Frail Scale assessment * Written informed consent Exclusion Criteria: * Emergency surgery * Active bleeding or hemodynamic instability * Vasopressor or inotropic support before induction * No oral intake on the evening before surgery (e.g., nasogastric decompression, ileus, full bowel preparation) * Permanent pacemaker or implanted device suppressing chronotropic response * Atrial fibrillation or other arrhythmias impairing the reliability of oscillometric blood pressure measurement

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View on ClinicalTrials.gov

Source: ClinicalTrials.gov (NCT07914920). StuddyBuddy aggregates publicly available trial information.