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NCT07915388
Comparative Study of Post-Varicocelectomy Myo-inositol vs. Antioxidants vs. Surgery Alone in Infertile Men
Conditions: Myo-inositol, Post Varicocelectomy, Infertile Men, Varicocele
Sex: Male
Ages: 18 Years – 50 Years
Healthy volunteers: No
Phase: PHASE3
Enrollment: 150
Sponsor: Fayoum University Hospital
Location: Mohamed Mahmoud Dogha Al Fayyum
Summary
The purpose of this open-label, 3-arm randomized controlled trial is to compare the clinical efficacy and safety of adding oral myo-inositol versus conventional oral antioxidants (vitamin C, L-carnitine, and zinc) versus surgery alone following microscopic subinguinal varicocelectomy in infertile adult males with clinical varicocele.
Eligibility Criteria
Inclusion Criteria:
* Adult male patients.
Clinically palpable Grade II or Grade III varicocele undergoing varicocelectomy.
Presence of primary or secondary infertility.
Impaired semen analysis parameters.
Reduced testicular volume.
Exclusion Criteria:
Pediatric (infants) or elderly populations.
Sub-clinical varicocele.
History of previous varicocelectomy operations.
Systemic vascular or medical diseases affecting arterial flow (e.g., diabetes mellitus, hypertension, liver disease, hypercholesterolemia).
Active genital tract infections.
Hormonal abnormalities or autism.
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Source: ClinicalTrials.gov (NCT07915388). StuddyBuddy aggregates publicly available trial information.
