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NCT07916545
Effect of Ascorbic Acid-Loaded I-PRF With Partially Demineralized Dentin Graft on Alveolar Ridge Preservation
Conditions: Alveolar Ridge Preservation Post-Extraction Bone Healing Dental Implant Site Development Tooth Loss, Alveolar Bone Regeneration Following Odontectomy, Assisted Alveolar Bone Healing After Dental Extraction, Alveolar Bone Preservation
Sex: All
Ages: 18 Years – 60 Years
Healthy volunteers: Yes
Phase: NA
Enrollment: 48
Sponsor: Nahda University
Summary
The goal of this clinical trial is to find out which treatment best preserves the jawbone after tooth extraction in adults planning to receive a dental implant later.
The study will investigate whether adding vitamin C to a mixture of tooth particles and a material prepared from the participant's own blood helps preserve the jawbone and improve bone healing.
The main questions it aims to answer are
* Does adding vitamin C help preserve the width of the jawbone after tooth extraction?
* Does it improve new bone formation compared with the other treatments?
Researchers will compare three treatments to determine whether adding a blood-based material, with or without vitamin C, improves bone preservation.
1. The first group will receive small particles prepared from their own extracted tooth.
2. The second group will receive tooth particles mixed with a healing material prepared from their own blood.
3. The third group will receive tooth particles mixed with the same blood-based material containing vitamin C.
Participants will undergo tooth extraction and receive one of these treatments. They will attend follow-up visits during the healing period.
Researchers will:
* Examine the treated area during follow-up visits.
* Take three-dimensional dental scans before treatment and four months later to measure changes in jawbone width and height.
* Collect a small bone sample during dental implant placement to examine new bone formation and healing.
The study will help determine whether adding vitamin C to the blood-based material provides additional benefits for preserving the jawbone before dental implant placement.
Eligibility Criteria
Inclusion Criteria:
* Patients aged 18-60 years. ⁴⁷
* ASA Type I medically healthy patients with no significant medical history. ⁴⁷
* Non-restorable teeth indicated for extraction followed by delayed implant placement. ⁴⁸
* Patients eligible for immediate implant placement but facing factors that prevent implant placement at the time of extraction. ⁴⁸
* Patients requiring alveolar ridge preservation before planned dental implant placement.
* Presence of ST IB sockets after extraction. ⁴²-⁴⁴
* periodontally healthy adjacent teeth. ⁴⁸
* Adequate oral hygiene plaque index ≤15% and willingness to comply with the study protocol and follow-up visits. ⁴⁷
* Cooperative patients willing to comply with the 4-month follow-up period. ⁴⁷
* Ability to understand and sign the informed consent form. ⁴⁷
Exclusion Criteria:
* Uncontrolled systemic diseases affecting bone healing (e.g., uncontrolled diabetes mellitus).
* History of radiotherapy or chemotherapy involving the head and neck region.
* Current use of medications known to influence bone metabolism (e.g., bisphosphonates, denosumab, long-term corticosteroids).
* Smokers or tobacco users.
* Pregnancy or lactation.
* Acute uncontrolled infection extraction site.
* Patients with poor oral hygiene or untreated active periodontal disease.
* Psychiatric patients, or those with a learning disability, or those unable to give consent
* Patients unable or unwilling to attend follow-up visits.
Source: ClinicalTrials.gov (NCT07916545). StuddyBuddy aggregates publicly available trial information.