Alveolar Bone Regeneration Using Advanced Platelet-Rich Fibrin Combined With Strontium-Doped Hydroxyapatite

This study aims to evaluate the effectiveness of advanced platelet-rich fibrin (A-PRF) combined with strontium-doped hydroxyapatite (Sr-HA) in enhancing alveolar bone regeneration following tooth extraction compared with spontaneous socket healing.

Inclusion Criteria: * Patients aged between 18 and 60 years. * Both male and female patients. * Indicated for extraction of teeth with preservation of intact extraction sockets. * Presence of adequate surrounding bone walls suitable for socket preservation. * Good oral hygiene and acceptable plaque control. * Systemically healthy patients or those with medically controlled conditions that do not interfere with bone healing. * Ability and willingness to comply with the study protocol and follow-up visits. Exclusion Criteria: * Pregnancy or lactation. * Current smokers or tobacco users. * Uncontrolled diabetes mellitus or systemic diseases affecting bone metabolism or wound healing. * History of radiotherapy or chemotherapy involving the head and neck region. * Active acute infection at the extraction site. * History of bisphosphonate therapy or long-term corticosteroid use. * Bleeding disorders or anticoagulant therapy contraindicating blood collection. * Previous regenerative procedures at the intended surgical site within the preceding six months. * Patients unable or unwilling to attend scheduled follow-up visits.