ELATE Study: Evaluating Large-vessel Acute Thrombectomy in Extended Time Window

The ELATE study is a prospective, observational study designed to evaluate the clinical outcomes and safety profile of endovascular thrombectomy compared with best medical treatment alone in patients presenting with acute ischemic stroke due to anterior large vessel occlusion within 24 to 72 hours from stroke onset or last known well.

Inclusion Criteria: * Age ≥ 18 years * Presentation with acute ischemic stroke within 24 to 72 hours of stroke onset or last known well. * Baseline NIHSS ≥ 8 (If patients have NIHSS \< 8 at admission and experienced END to an NIHSS score ≥ 8 or higher, they also were included if they were 24 to 72 hours from the LKW at this point) * Clinical diagnosis of AIS due to anterior circulation LVO (internal carotid artery (ICA) extracranial or intracranial segment, middle cerebral artery (MCA) M1 and proximal M2 segment) on brain imaging (CTA/MRA). * Imaging criteria: must fulfill at least one: * 1\) Core-penumbra mismatch on CT perfusion (CTP) or MR perfusion (MRP) assessed: infarct core volume ≤ 70mL, mismatch ratio ≥ 1,8 and mismatch volume ≥ 15mL. * 2\) ASPECTS ≥6 on non-contrast CT or diffusion-weighted imaging (DWI). * Written informed consent (by patient or proxy, according to local requirements) Exclusion Criteria: * Intracranial hemorrhage identified by CT or MRI * Pre-stroke modified Rankin Score (mRS) score of \>2 (indicating previous disability) * Any terminal illness such that the patient has a life expectance of less than 1 year. * Patients with active cancer and undergoing treatment for cancer are excluded * Pregnancy