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Recruiting NCT07930026

Platelet-Rich Plasma for Bone Healing in Maxillary and Mandibular Fractures

Conditions: Mandibular Fractures, Maxillary Fractures

Sex: All
Ages: 18 Years – N/A
Healthy volunteers: No
Phase: NA
Enrollment: 40
Sponsor: CMH Lahore Medical College and Institute of Dentistry

Location: Institute of Dentistry; CMH Lahore Medical College Lahore Punjab Province

Summary

The goal of this clinical trial is to learn if platelet-rich plasma (PRP) made from the patient's own blood helps broken jaw bones heal faster and stronger in adults with fractures of the upper jaw (maxilla) or lower jaw (mandible). The main questions it aims to answer are: * Does adding PRP during fracture surgery increase bone density at the fracture site at 6 months compared with surgery alone? * Is the effect of PRP on bone healing similar in upper jaw and lower jaw fractures? Researchers will compare patients who receive standard fracture fixation with titanium plates plus PRP to patients who receive the same fixation without PRP, to see if PRP improves bone healing. Participants will: * Give a small blood sample (12 ml) before surgery, from which PRP will be prepared (PRP group only) * Undergo surgery under general anaesthesia to fix the fracture with two titanium plates and screws * Take antibiotics and anti-inflammatory medicine for one week after surgery * Return for check-ups and a CBCT (3D dental X-ray) scan at 1 week, 3 months, and 6 months after surgery to measure bone healing

Eligibility Criteria

Inclusion Criteria: * Age 18 years or older * Fracture of the maxilla or mandible confirmed by clinical examination and panoramic radiograph * Fracture requiring open reduction and internal fixation with titanium miniplates * Willing and able to provide written informed consent and to attend all follow-up visits up to 6 months Exclusion Criteria: * Uncontrolled diabetes mellitus * Bleeding or coagulation disorders (e.g., haemophilia, von Willebrand disease) * Platelet disorders or thrombocytopenia * Chronic renal failure * Hepatic disease * Active malignancy, or current chemotherapy or radiotherapy * Osteoporosis or other metabolic bone disease * Immunocompromised state (e.g., HIV/AIDS, long-term corticosteroid or immunosuppressive therapy) * Current use of anticoagulant or antiplatelet medication * Pregnancy or lactation * Multiple or pathological fractures * Refusal to provide informed consent

Interested in this study? View the official listing for contact and enrollment details.

View on ClinicalTrials.gov

Source: ClinicalTrials.gov (NCT07930026). StuddyBuddy aggregates publicly available trial information.